We have quite a few charitable organisations managing their accounts on QuickFile. You can segregate the different income streams by using different nominal codes, or you can tag income to different projects. I would generally suggest the former option, it’s a little easier to manage.
If you search for the term “Charity” on this forum you can find many related discussion about managing charity accounts and other specifics that affect charities.
A Power User Subscription (£45 per annum) isn’t required at this time, although it does provide quite a few enhanced features. By the end of 2015 it will however be required for Large and Extra Large accounts. More details here.