Hi - I assume you are a sole trader and you have registered the business with hmrc and got your UTR (unique taxpayer reference?
When is your year-end? The year-end close in QF is very straight-forward as it will just create a year-end journal, capturing sales (business income) and any other balances on the nominal ledgers. I found the on-line submission for self-assessment quite easy and you just follow the steps, making sure you tailor your return to your particular circumstances. Basically I did it all myself (without the need for an accountant).